Do You Know What Nrf2 is? (NF-E2-related Factor 2)

Do You Know How Nrf2 Can Affect You!

Your Health Will Never Be the Same!

Get Back to Great Health Now With Nrf2!


So What is Nrf2?


NF-E2 related factor 2 (Nrf2) is a member of the cap 'n collar family of basic leucine zipper transcription factors. By binding antioxidant response elements (AREs), Nrf2 activates the transcription of genes encoding antioxidant and phase II drug-metabolizing enzymes needed to protect cells against oxidative damage. Transcriptional targets regulated by Nrf2 include genes encoding glutathione S-transferases, superoxide dismutase-1, and heme oxygenase-1



Laymen's Terms:

Nrf2 (NF-E2-Related Factor 2), a transcription factor in humans that is encoded by the NFE2L2 gene, regulates the expression of a set of antioxidant and detoxifying genes, protecting the body from the ravages of oxidative stress-related conditions, Including (but not limited to) those effecting the brain and nervous system. In an unstressed state, Nrf2 is anchored in the cytoplasm by its specific inhibitor, Keap1 (Kelch-like ECH-Associated Protein 1). Keap1 functions as a sensor for oxidants and electrophilic xenobiotics. In the presence of any of these substances, Keap1 gives up its inhibition of Nrf2. This action stabilizes Nrf2, allowing it to accumulate in the nucleus and bind to the Antioxidant Response Element (ARE) located in the enhancers of its target genes. Under this circumstance, Nrf2 then up-regulates a variety of antioxidant enzymes and detoxifying proteins.

In Other Words:

Protandim’s actions result from its ability to activate the transcription factor known as Nrf2. Protandim contains 5 ingredients that are known to scientists as Nrf2 activators. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA. That DNA consists of about 25,000 genes and the products of those genes make you who you are and what you are. There’re unique for each person. DNA is what makes you a human being, what gives you your personality, what gives you your physical traits.

When this protein messenger called Nrf2 is activated, it enters the nucleus of every cell and it turns on several hundred of these 25,000 genes. And the genes that it turns on, or turns up, are known collectively as “survival genes.” What is a survival gene? These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress which is due to the over production of free radicals and other oxidants.

Nrf2 also affects another hundred or so genes by turning them down, not up. Included in these genes are pro-inflammatory and pro-fibrotic genes.

Inflammation accompanies many different disease processes. Everyone is familiar with inflammatory diseases like arthritis, but any time you get traumatic injuries, you sprain your ankle, bruise yourself, there is swelling and pain and redness that characterize inflammation. The process of inflammation is designed, in part, to prevent infection. One of the ways your body prevents infection is to kill invading microorganisms by intentionally making toxic free radicals. Thus the pain, redness and swelling in a cut are not so much from infection, but from inflammation as your body responds to the possibilities of an infection.

What are Pro-Fibrotic genes? Following inflammation in many kinds of diseases or traumatic injury is a process of scar tissue formation that scientists refer to as “fibrosis”. A number of genes turn on that process. And while fibrosis can be a good thing if you’re healing a cut, in many other diseases it is a bad thing. For example, many older people die each year from heart failure-- the failure of the pumping action of the heart due to this process of fibrosis. This is quite a different process from “hardening of the arteries” or atherosclerosis, which leads to heart attacks and strokes.

So, Protandim, as a Nrf2 activator, activates survival genes, such as antioxidant genes that keep us safe from free radicals and oxidants. It also turns down genes that perpetuate inflammation and genes that encourage slow, progressive fibrosis to take place. Together, these actions provide a remarkable promise of protection from many kinds of age-related diseases.

Protandim is among the very first of the products that are appearing, and will appear, as Nrf2 activators. It is, as far as we know, the first potent Nrf2 Activator that is commercially available.


Watch This Video To Hear Dr. McCord on Nrf2 Activator

What Can This Product Do For You?

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"It goes beyond antioxidants and goes to genetic engineering"