Do You Know What Nrf2
is? (NF-E2-related Factor 2)
Do You Know How
Nrf2 Can Affect You!
Your Health Will Never
Be the Same!
Get Back to Great
Health Now With Nrf2!
What is Nrf2?
NF-E2 related factor
2 (Nrf2) is a member of the cap 'n collar family of basic leucine
zipper transcription factors. By binding antioxidant response
elements (AREs), Nrf2 activates the transcription of genes encoding
antioxidant and phase II drug-metabolizing enzymes needed to protect
cells against oxidative damage. Transcriptional targets regulated
by Nrf2 include genes encoding glutathione S-transferases, superoxide
dismutase-1, and heme oxygenase-1
Nrf2 (NF-E2-Related Factor 2), a
transcription factor in humans that is encoded by the NFE2L2 gene,
regulates the expression of a set of antioxidant and detoxifying
genes, protecting the body from the ravages of oxidative stress-related
conditions, Including (but not limited to) those effecting the
brain and nervous system. In an unstressed state, Nrf2 is anchored
in the cytoplasm by its specific inhibitor, Keap1 (Kelch-like
ECH-Associated Protein 1). Keap1 functions as a sensor for oxidants
and electrophilic xenobiotics. In the presence of any of these
substances, Keap1 gives up its inhibition of Nrf2. This action
stabilizes Nrf2, allowing it to accumulate in the nucleus and
bind to the Antioxidant Response Element (ARE) located in the
enhancers of its target genes. Under this circumstance, Nrf2 then
up-regulates a variety of antioxidant enzymes and detoxifying
actions result from its ability to activate the transcription
factor known as Nrf2. Protandim contains 5 ingredients that are
known to scientists as Nrf2 activators. Nrf2 is a protein messenger
contained in every cell of the body that sends information to
the cell’s DNA. That DNA consists of about 25,000 genes
and the products of those genes make you who you are and what
you are. There’re unique for each person. DNA is what makes
you a human being, what gives you your personality, what gives
you your physical traits.
When this protein
messenger called Nrf2 is activated, it enters the nucleus of every
cell and it turns on several hundred of these 25,000 genes. And
the genes that it turns on, or turns up, are known collectively
as “survival genes.” What is a survival gene? These
genes enable cells to survive in the face of several different
kinds of stress, especially oxidative stress which is due to the
over production of free radicals and other oxidants.
Nrf2 also affects
another hundred or so genes by turning them down, not up. Included
in these genes are pro-inflammatory and pro-fibrotic genes.
many different disease processes. Everyone is familiar with inflammatory
diseases like arthritis, but any time you get traumatic injuries,
you sprain your ankle, bruise yourself, there is swelling and
pain and redness that characterize inflammation. The process of
inflammation is designed, in part, to prevent infection. One of
the ways your body prevents infection is to kill invading microorganisms
by intentionally making toxic free radicals. Thus the pain, redness
and swelling in a cut are not so much from infection, but from
inflammation as your body responds to the possibilities of an
What are Pro-Fibrotic
genes? Following inflammation in many kinds of diseases or traumatic
injury is a process of scar tissue formation that scientists refer
to as “fibrosis”. A number of genes turn on that process.
And while fibrosis can be a good thing if you’re healing
a cut, in many other diseases it is a bad thing. For example,
many older people die each year from heart failure-- the failure
of the pumping action of the heart due to this process of fibrosis.
This is quite a different process from “hardening of the
arteries” or atherosclerosis, which leads to heart attacks
So, Protandim, as
a Nrf2 activator, activates survival genes, such as antioxidant
genes that keep us safe from free radicals and oxidants. It also
turns down genes that perpetuate inflammation and genes that encourage
slow, progressive fibrosis to take place. Together, these actions
provide a remarkable promise of protection from many kinds of
Protandim is among
the very first of the products that are appearing, and will appear,
as Nrf2 activators. It is, as far as we know, the first potent
Nrf2 Activator that is commercially available.
Watch This Video
To Hear Dr. McCord on Nrf2 Activator
What Can This Product Do For
"It goes beyond antioxidants
and goes to genetic engineering"